A COMPARATIVE  EVALUATION OF TETRACYCLINE CONTAINING MICROSPHERES AND COMMERCIALLY AVAILABLE TETRACYCLINE FIBERS TO EVALUATE THEIR EFFICACY IN PERIODONTAL POCKET THERAPY - A CLINICAL AND MICROBIOLOGICAL STUDY

Dr. Manish kumar; Dr. Mona Sharma; Dr. Vivek govila; Dr. Vineeta Mittal; Prof.(Dr.) Shailendra K. Saraf

Volume : VI, Issue : VIII, August - 2017

A COMPARATIVE EVALUATION OF TETRACYCLINE CONTAINING MICROSPHERES AND COMMERCIALLY AVAILABLE TETRACYCLINE FIBERS TO EVALUATE THEIR EFFICACY IN PERIODONTAL POCKET THERAPY - A CLINICAL AND MICROBIOLOGICAL STUDY

Dr. Manish Kumar, Dr. Mona Sharma, Dr. Vivek Govila, Dr. Vineeta Mittal, Prof. Dr. Shailendra K. Saraf

Abstract :

The aim of this clinical trial was to compare the efficacy of Tetracycline containing

Microspheres (TM) and commercially available tetracycline containing Fibers (TF) as local

drug-delivery system in the treatment of periodontal pocket therapy. A randomized split mouth design was adopted for allocating, 50 sites in different treatment modalities : SRP + TF and SRP + TM. Periodontal Plus AB was used for TF group and prepared microsphere containing Tetracycline was used for TM group. Clinical parameters were seen at baseline, 1 and 6 months and microbiological analysis was done at baseline and 3 months. Clinical parameters that were recorded were PI, GI, PD and RAL. In microbiological analysis, CFU of Prevotella Intermedia were seen. The result revealed that both groups showed a statistically significant reduction in clinical parameters and microbiological parameters at 1, 3 and 6 months compared to baseline and TM was more effective in comparison to TF.