A Clinical study to evaluate the effects of perioperative oral Amantadine on postoperative pain and requirement of morphine in Total Abdominal Hysterectomy

Dr (Lt Col) Amit Dua; Dr Mary Samuel

Volume : V, Issue : VI, June - 2016

A Clinical study to evaluate the effects of perioperative oral Amantadine on postoperative pain and requirement of morphine in Total Abdominal Hysterectomy

Dr Lt Col Amit Dua, Dr Mary Samuel

Abstract :

 Most of the patients about to undergo a surgery are anxious about post operative pain. Evidence reveals that adequate control of post operative pain is achieved only in a minority of patients. Therefore the conquest of better pain management continues in our clinical practice. Preemptive analgesia can help control postoperative pain and decrease the postoperative analgesic requirements. In this randomised blind study, the analgesic and the opioid sp� effect of oral amantadine, which is a NMDA receptor antagonist was studied. 60 women undergoing abdominal hysterectomy were randomised into 2 groups of 30 each. One group received oral amantadine night before and 2 hour before surgery and the other received placebo at the same time. Postoperatively the patients were given Inj Morphine for pain whenever the VAS score was more than 4 and they were observed for 48hrs postoperatively. The results were statistically analysed and it was observed that the average time for the first dose of morphine was significantly more in Amantadine group. VAS score in the Amantadine group were significantly lower and there were no major adverse effects with amantadine.