A case of clinically significant Anti-M antibody

Dr. KAUSHIK R. PRAJAPATI; Dr. PARUL D. BHANSALI; Dr. HARSHA R. GAJJAR; Dr. ZENNY H. CHAVDA

Volume : VI, Issue : VII, July - 2017

A case of clinically significant Anti-M antibody

Dr. Kaushik R. Prajapati, Dr. Parul D. Bhansali, Dr. Harsha R. Gajjar, Dr. Zenny H. Chavda

Abstract :

The MNS antigen system is a human blood group system based upon two genes; glycophorin A and glycophorin B, located on chromosome number 4. There are currently 46 antigen in the system, but the five most important antigens are M,N,S,s and U. Most anti -M antibodies are naturally occurring IgM antibodies. Anti-M reacting at room temperature can be a cause of blood group discrepancy. Antibodies to Anti-M antigen are associated with hemolytic transfusion reaction if antigen reacting incompatible pack cells given